Genetics of complex diseases
نویسندگان
چکیده
منابع مشابه
Role of Mitochondrial Genetics in Complex Diseases
The study of genetic disease is often centered on the human nuclear genome consisting of ~3.1 billion nucleotides and 25,000–30,000 genes located on the 23 pairs of chromosomes, whereas the mitochondrial genome has received less attention. Each cell contains numerous mitochondria and each mitochondrion contains several copies of mitochondrial DNA (mtDNA). Thus, a cell contains several thousand ...
متن کاملIlluminating the genetics of complex human diseases
In 2007, Zhao et al. [1] proposed a unified genetic theory of sporadic and inherited autism spectrum disorders to explain the complex familial patterns observed. The model explains why most families have a low risk of autistic children with an overall incidence rate of approximately 1 in 150 births, but a small minority of families have a 50% risk for male offspring. Their model links these two...
متن کاملPopulation genetics of rare variants and complex diseases.
OBJECTIVES Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high-throughput genome sequencing technologies is a central challenge faced by human geneticists today. We hypothesize that the variants involved in complex diseases are likely to exhibit non-neutral evolutionary signatures. Uncovering the evolutionary history of all variants is therefore ...
متن کامل"Good enough solutions" and the genetics of complex diseases.
In this Emerging Science Review, we discuss a systems genetics strategy, which we call gene module association study (GMAS), as a novel approach complementing genome-wide association studies (GWAS), to understand complex diseases by focusing on how genes work together in groups rather than singly. The first step is to characterize phenotypic differences among a genetically diverse population. T...
متن کاملBasic concepts in the study of diseases with complex genetics.
Most diseases run in families--this is also true of virtually all psychiatric disorders. Twin and adoption studies have shown that most psychiatric disorders have a genetic component, yet very few genetic factors are known, as is true for most disorders with a complex genetic origin. Here I review, for nongeneticists, some of the basic terminology and concepts used when studying complex genetic...
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ژورنال
عنوان ژورنال: Journal of Zhejiang University SCIENCE B
سال: 2006
ISSN: 1673-1581,1862-1783
DOI: 10.1631/jzus.2006.b0167